Manchester City will face Liverpool in the headline fixture of the FA Cup quarter-final draw, while giant-killing Port Vale make the trip to Stamford Bridge to take on Chelsea.
City and Liverpool will meet for the first time in the competition since the 2021-22 semi-finals, a game Liverpool won at Wembley Stadium 3-2, thanks to Sadio Mane's brace.
Port Vale's reward for their win over Sunderland is a tie with Liam Rosenior's Chelsea, who are still in the hunt for a ninth FA Cup crown after edging a six-goal thriller with Wrexham.
The League One strugglers are in the FA Cup quarter-finals for only the second time in their history, after 1953-54, and will be looking to add another notable scalp to their list.
Southampton, who also stunned Premier League opposition in Fulham during the fifth round, will welcome top-flight leaders Arsenal to St. Mary's on the weekend of 4-5 April.
The final fixture in the quarter-finals will see the winners of Monday's clash between London rivals West Ham and Brentford take on Daniel Farke's Leeds United side.
The #EmiratesFACup quarter-final draw
— Emirates FA Cup (@EmiratesFACup) March 9, 2026
FA Cup quarter-final draw in full:
Southampton v Arsenal
Chelsea v Port Vale
Manchester City v Liverpool
West Ham or Brentford v Leeds United